ΔNp63 is upregulated during salivary gland regeneration following duct ligation and irradiation in mice

AbstractThe transcription factor p63, a component of the p53 family, has important functions in development, homeostasis, and regeneration of epithelial tissues. However, the role of p63 in the regeneration of exocrine glands, including the salivary glands (SGs), has not been fully investigated. We investigated p63 expression in SG regeneration induced by duct ligation and irradiation. The expression of ΔNp63, a p63 isoform, increased and was co‐localized with Keratin5 (Krt5) during the regeneration process of SGs. Some ΔNp63‐ and Krt5‐positive cells were myoepithelial cells. Furthermore, ΔNp63 expression was regulated by FGF7 stimulation via p38 MAPK phosphorylation and affected SG morpho genesis. These results suggest that ΔNp63 is essential for SG regeneration and may be a new target for regenerative treatment.

Source: FEBS Letters - August 3, 2020 Category: Biochemistry Authors: Kazuki Ikai, Manabu Sakai, Hitomi Minagi, Nao Gojo, Takayoshi Sakai Tags: RESEARCH LETTER Source Type: research