A DNAzyme cascade for amplified detection of intracellular miRNA.

A DNAzyme cascade for amplified detection of intracellular miRNA.
Chem Commun (Camb). 2020 Aug 03;:
Authors: Wu Y, Li J, Quan K, Meng X, Yang X, Huang J, Wang K
Abstract
Inspired by the natural enzyme cascade reaction, an artificial DNAzyme cascade system is developed for the amplified detection of intracellular miR-141. The results showed that the method enormously enhanced the readout of the fluorescence signal and achieved a femtomolar detection limit.
PMID: 32744553 [PubMed - as supplied by publisher]

Source: Chemical Communications - August 2, 2020 Category: Chemistry Authors: Wu Y, Li J, Quan K, Meng X, Yang X, Huang J, Wang K Tags: Chem Commun (Camb) Source Type: research