Total T4 rise in pregnancy: a relook?

ConclusionRise in total T4 in second trimester pregnancy is only around 25% as compared to first trimester value and 35% than the non-pregnant value. Hence multiplying non-pregnant T4 value by 1.5 may actually over-diagnose maternal hypothroxinemia and lead to inappropriate diagnosis and treatment of isolated maternal hypothyroxinemia in a significant proportion of subjects.

http://link.springer.com/10.1186/s13044-020-00088-5

Source: Thyroid Research - July 30, 2020 Category: Endocrinology Source Type: research