Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy.

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy.
Chem Commun (Camb). 2020 Jul 29;:
Authors: Zhang Y, Liu X, Lin Y, Lian B, Lan W, Iovanna JL, Liu X, Peng L, Xia Y
Abstract
Novel nucleoside derivatives were developed using the strategy of "terminal N,N-dimethylation" to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.
PMID: 32724994 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 28, 2020 Category: Chemistry Authors: Zhang Y, Liu X, Lin Y, Lian B, Lan W, Iovanna JL, Liu X, Peng L, Xia Y Tags: Chem Commun (Camb) Source Type: research