A population ‐based study of the association between hemodialysis and cognitive impairment

This study assesses the risk of cognitive impairment among a nationwide cohort of new hemodialysis patients derived from the NHIRD.ResultsA total of 4330 patients were assigned to the dialysis group and 17  320 patients were assigned to the control group. A total of 2103 of the patients developed cognitive impairment within 2 years after the date of dialysis initiation. Patients who developed cognitive impairment were older (69.85 ± 11.56) than their counterparts who did not develop cognitive impairment (58.58 ± 14.77;P <  .001). The log‐rank test of Kaplan‐Meier analysis revealed a higher risk of cognitive impairment in the hemodialysis group than in the non‐hemodialysis group (P <  .001). The interval between dialysis initiation and the onset of cognitive impairment was 98.66 ± 46.39 months among non‐dialysis subjects and 53.45 ± 41.90 months among dialysis subjects, and the between‐group difference was significant (P <  .001). The Cox Proportional Hazard Model revealed that after controlling for gender, age, residence, and comorbidities, hemodialysis was shown to have a significant impact on cognitive impairment (Hazard Ratio [HR]: 1.44; 95% confidence interval [CI]: 1.29‐1.60). Furthermore, the risk of develo ping cognitive impairment increased with age (HR: 1.07; 95% CI: 1.06‐1.08).DiscussionHemodialysis was associated with cognitive impairment. There was a significant association between age and cognitive im...
Source: Asia-Pacific Psychiatry - Category: Psychiatry Authors: Tags: ORIGINAL ARTICLE Source Type: research