Two new phenylpropanoids from the resin of Styrax tonkinensis (Pierre) Craib ex Hartw

AbstractAbstractTwo new phenylpropanoids, named stytonkinol A (1) and stytonkinol B (2), have been isolated from the resin ofStyrax tonkinensis (Pierre) Craib ex Hartw. Their structures were determined by spectroscopic analysis, including 1D and 2D NMR, and HR-ESI –MS. Two isolated compounds were assayed for cytotoxic activities against five tumor cell lines (HepG-2, A549, Hela, MCF-7, and PC-3) by Cell Counting Kit-8 (CCK-8) test in vitro. The cytotoxic effectiveness observed against Hela, and MCF-7 cell lines of compound1 were superior or similar to the positive control cisplatin (IC50 values of 40.95 and 47.36  μM), with IC50 values of 26.75 and 45.16  μM, respectively, while it showed moderate cytotoxic activities against the HepG-2 and PC-3 cell lines. Compound2 showed moderate cytotoxic activities on cells MCF-7 with IC50 values of 57.1  μM.Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research