Numerical Bifurcation Analysis of Pacemaker Dynamics in a Model of Smooth Muscle Cells.

Numerical Bifurcation Analysis of Pacemaker Dynamics in a Model of Smooth Muscle Cells. Bull Math Biol. 2020 Jul 16;82(7):95 Authors: Fatoyinbo HO, Brown RG, Simpson DJW, van Brunt B Abstract Evidence from experimental studies shows that oscillations due to electro-mechanical coupling can be generated spontaneously in smooth muscle cells. Such cellular dynamics are known as pacemaker dynamics. In this article, we address pacemaker dynamics associated with the interaction of [Formula: see text] and [Formula: see text] fluxes in the cell membrane of a smooth muscle cell. First we reduce a pacemaker model to a two-dimensional system equivalent to the reduced Morris-Lecar model and then perform a detailed numerical bifurcation analysis of the reduced model. Existing bifurcation analyses of the Morris-Lecar model concentrate on external applied current, whereas we focus on parameters that model the response of the cell to changes in transmural pressure. We reveal a transition between Type I and Type II excitabilities with no external current required. We also compute a two-parameter bifurcation diagram and show how the transition is explained by the bifurcation structure. PMID: 32676881 [PubMed - in process]
Source: Bulletin of Mathematical Biology - Category: Bioinformatics Authors: Tags: Bull Math Biol Source Type: research