Caspofungin suppresses zymosan-induced cytokine and chemokine release in THP-1 cells: Possible involvement of the spleen tyrosine kinase pathway

Systemic inflammatory response syndrome and sepsis are considered to contribute to hypercytokinemia in both patients with severe infection and immunocompromised condition. Past research has demonstrated that antibiotics and antifungals not only have antimicrobial efficacy but also affect the immune system. We previously examined whether immune cells were modulated by antibiotics such as tetracyclines or macrolides. The modulation of lipopolysaccharide-stimulated cells by those agents was elucidated.

Source: Translational Research - July 16, 2020 Category: Research Authors: Kazuhiro Itoh, Hiroko Shigemi, Kazuyasu Chihara, Kiyonao Sada, Takahiro Yamauchi, Hiromichi Iwasaki Source Type: research