Effect of IFN- γ on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model

The skin provides a continuously renewed protective barrier formed by differentiating keratinocytes. The outermost layer of the skin, the epidermis, can be divided into four layers: stratum basale, stratum spinosum, stratum granulosum and stratum corneum. These layers are characterized by the properties and degree of differentiation of the keratinocytes, as the undifferentiated cells move from the basal layer to the outermost cornified layer [1]. Keratinocytes can release anti-microbial peptides and inflammatory cytokines when activated by an immune response caused by injury, or stimulated by exogenous factors such as UV-radiation [2].

Source: Journal of Dermatological Science - July 16, 2020 Category: Dermatology Authors: Anna Gustafsson, Zdenka Prgomet, Skaidre Jankovskaja, Tautgirdas Ruzgas, Johan Engblom, Lars Ohlsson, Anette Gj örloff Wingren Source Type: research