MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells

MNDA (Myeloid Nuclear Differentiation Antigen) is a member of the Hematopoietic Interferon (IFN)-inducible Nuclear proteins with a 200-amino acid repeat (IFI200/HIN-200) family. These factors are also annotated as PYHIN factors due to the presence of an N-terminal pyrin domain (PYD) and C-terminal HIN domain(s) [1-4]. Their expression can be modulated by signalling pathways, including the IFN pathway, and several PYHIN factors relocate to the cytoplasm during the cell cycle or upon induction of stress [5-7].

Source: Experimental Hematology - July 14, 2020 Category: Hematology Authors: Stefania Bottardi, Romain Guieze, Vincent Bourgoin, Nasser Fotouhi-Ardakani, Aurore Doug é, Anaïs Darracq, Yahia A. Lakehal, Marc G. Berger, Luigina Mollica, Jacques-Olivier Bay, James G. Omichinski, Eric Milot Source Type: research