You Say You Want a Resolution (of Fibrosis).

You Say You Want a Resolution (of Fibrosis). Am J Respir Cell Mol Biol. 2020 Jul 08;: Authors: Atabai K, Yang CD, Podolsky MJ Abstract In pathological fibrosis, aberrant tissue remodeling with excess extracellular matrix leads to organ dysfunction and eventual morbidity. Diseases of fibrosis create significant global health and economic burdens and are often deadly. Although fibrosis has traditionally been thought of as an irreversible process, a growing body of evidence demonstrates that organ fibrosis can reverse in certain circumstances, especially if an underlying cause of injury can be removed. This body of evidence has uncovered more and more contributors to persistent and non-resolving tissue fibrosis. Here we review the present knowledge on resolution of organ fibrosis and restoration of near-normal tissue architecture. We emphasize three critical areas of tissue homeostasis that are necessary for fibrosis resolution, namely the elimination of matrix-producing cells, the clearance of excess matrix and the regeneration of normal tissue constituents. In so doing, we also highlight how profibrotic pathways interact with one another and where there may be therapeutic opportunity to intervene and remediate pathological persistent fibrosis. PMID: 32640171 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - Category: Respiratory Medicine Authors: Tags: Am J Respir Cell Mol Biol Source Type: research