Morusalisins A-F, six new Diels-Alder type adducts, as potential PTP1B inhibitors from cell cultures of Morus alba.

Morusalisins A-F, six new Diels-Alder type adducts, as potential PTP1B inhibitors from cell cultures of Morus alba.
Fitoterapia. 2020 Jul 03;:104682
Authors: Su C, Duan Y, Tian J, Liu J, Xie K, Chen D, Ye F, Chen R, Dai J
Abstract
Six new Diels-Alder type adducts, morusalisins A-F (1-6), were isolated from Morus alba cell cultures. The structures of 1-6 were determined by extensive spectroscopic data analysis, including HRESIMS, NMR, and ECD experiments. Furthermore, compounds 1-6 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 1.14 to 2.24 μM, making them promising as bioactive compounds for anti-diabetic drug discovery.
PMID: 32628985 [PubMed - as supplied by publisher]

Source: Fitoterapia - July 2, 2020 Category: Biochemistry Authors: Su C, Duan Y, Tian J, Liu J, Xie K, Chen D, Ye F, Chen R, Dai J Tags: Fitoterapia Source Type: research