Eicosanoids: the Overlooked Storm in COVID-19?

Severe coronavirus-19 (COVID-19) symptoms, including systemic inflammatory response and multi-system organ failure, are now affecting thousands of infected patients and causing widespread mortality. Coronavirus infection causes tissue damage, which triggers the endoplasmic reticulum (ER) stress response and subsequent eicosanoid and cytokine storms. While pro-inflammatory eicosanoids including prostaglandins, thromboxanes, and leukotrienes are critical mediators of physiological processes such as inflammation, fever, allergy, and pain, their role in COVID-19 are poorly characterized.

https://ajp.amjpathol.org/article/S0002-9440(20)30332-1/fulltext?rss=yes

Source: American Journal of Pathology - July 6, 2020 Category: Pathology Authors: Bruce D. Hammock, Weicang Wang, Molly M. Gilligan, Dipak Panigrahy Tags: Mini-Review Source Type: research