miRNA-221 is elevated in cystic fibrosis airway epithelial cells and regulates expression of ATF6

Conclusions These results implicate miR-145, miR-221 and miR-494 in the regulation of ATF6 in CF bronchial epithelium, with miR-221 demonstrating structural and functional conservation between humans and mice. The altered miRNA expression evident in CF bronchial epithelial cells can affect expression of transcriptional regulators such as ATF6.
Source: Molecular and Cellular Pediatrics - Category: Cytology Source Type: research