Filoviruses Infect Rhesus Macaque Synoviocytes in  Vivo and Primary Human Synoviocytes in Vitro

The most commonly reported symptom of post –Ebola virus disease syndrome in survivors is arthralgia, yet involvement of the joints in acute or convalescent Ebola virus infection has not been well characterized in human patients or animal models. Through the use of immunohistochemistry, we found that the lining synovial intima of the stifle (knee) is a target for acute infection by Ebola virus/Kikwit, Ebola virus/Makona-C05, and Marburg virus/Angola in the rhesus macaque model. Furthermore, we found through histologic analysis, immunohistochemistry, RNAscope in situ hybridization, and transmission electron microscopy that synoviocytes of the stifle, shoulder, and hip are a target for mouse-adapted Ebola virus/Yambuku-Mayinga infection during acute disease in rhesus macaques.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular article Source Type: research