NAADP/SERCA3-Dependent Ca2+ Stores Pathway Specifically Controls Early Autocrine ADP Secretion Potentiating Platelet Activation.

Conclusions: Upon activation a NAADP/SERCA3 Ca2+ mobilization pathway initiates an early ADP secretion, potentiating platelet activation, and a secondary wave of ADP secretion driven by both an IP3/SERCA2b-dependent Ca2+ stores pathway and the NAADP/SERCA3 pathway. This does not exclude that Ca2+ mobilized from SERCA3 stores may also enhance platelet global reactivity to agonists. Because of its modulating effect on platelet activation, this NAADP-SERCA3 pathway may be a relevant target for anti-thrombotic therapy. PMID: 32588751 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32588751?dopt=Abstract

Source: Circulation Research - June 25, 2020 Category: Cardiology Authors: Feng M, Elaïb Z, Borgel D, Denis CV, Adam F, Bryckaert M, Rosa JP, Bobe R Tags: Circ Res Source Type: research

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