Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes

Preterm prelabor rupture of the membranes (PPROM) is frequently complicated by intraamniotic inflammatory processes such as intraamniotic infection and sterile intraamniotic inflammation. Antibiotic therapy is recommended to patients with PPROM to prolong the interval between this complication and delivery (latency period), reduce the risk of clinical chorioamnionitis, and improve neonatal outcome. However, there is a lack of information regarding whether the administration of antibiotics can reduce the intensity of the intraamniotic inflammatory response or eradicate microorganisms in patients with PPROM.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research Source Type: research