The Roles of Alternative Splicing in Tumor-immune Cell Interactions.

The Roles of Alternative Splicing in Tumor-immune Cell Interactions.
Curr Cancer Drug Targets. 2020 Jun 19;:
Authors: Wang Y, Zhang H, Jiao B, Nie J, Li X, Wang W, Wang H
Abstract
Alternative splicing (AS) plays a significant role in the hallmarks of cancer and can provide neoantigens for immunotherapy. Here, we summarize recent advances in immune system associated tumor specific-antigens (TSAs) produced by AS. We further discuss the regulating mechanisms involved in AS-mediated innate and adaptive immune responses and the anti-tumoral and pro-tumoral roles in different types of cancer. For example, ULBP1_RI, MLL5△21spe, NKp44-1△5, MHC-I△7, CD200S△1, 2, PVR α/β/γ/δ and IL-33 variants 1/2/3 act as regulators in solid tumors and IPAK4-L and, FOXP1ΔN100 exhibit functions in hematological cancers.
PMID: 32560607 [PubMed - as supplied by publisher]

Source: Current Cancer Drug Targets - June 18, 2020 Category: Cancer & Oncology Authors: Wang Y, Zhang H, Jiao B, Nie J, Li X, Wang W, Wang H Tags: Curr Cancer Drug Targets Source Type: research