Tetrabutylammonium tosylate as inert phase-transfer catalyst: The key to high efficiency SN2 radiofluorinations.

Tetrabutylammonium tosylate as inert phase-transfer catalyst: The key to high efficiency SN2 radiofluorinations.
Appl Radiat Isot. 2020 Sep;163:109195
Authors: Orlovskaya V, Antuganov D, Fedorova O, Timofeev V, Krasikova R
Abstract
Here we describe use of the tetrabutylammonium p-toluenesulfonate (TBAOTs) as an inert phase transfer catalyst allowing high efficient aliphatic radiofluorination of labeling precursors for the preparation of common radiotracers using only 0.2-1.2 mg of the substrates. With operational convenience (no need for azeotropic drying) and compatibility with the common types of strong anion-exchange cartridges (QMA), this method has a high potential for routine application in various automated synthesizers and offers significant costs reductions due to less precursors used.
PMID: 32561038 [PubMed - as supplied by publisher]

Source: Applied Radiation and Isotopes - June 22, 2020 Category: Radiology Authors: Orlovskaya V, Antuganov D, Fedorova O, Timofeev V, Krasikova R Tags: Appl Radiat Isot Source Type: research