The crosstalk between cellular reprogramming and senescence in aging and regeneration.

The crosstalk between cellular reprogramming and senescence in aging and regeneration.
Exp Gerontol. 2020 Jun 16;:111005
Authors: Chiche A, Chen C, Li H
Abstract
Aging is associated with diminished regenerative capacity and increased risk of chronic diseases. There is now compelling evidence suggests that aging process is reversible. Besides metabolic modification and systematic factors, both senescence elimination and cellular reprogramming showed beneficial effects on tissue regeneration and rejuvenation. Here we review recent studies on the interplay between cellular senescence and reprogramming. We discuss how both strategies could impact aging process and the possibility of combine them for more efficient regeneration and rejuvenation.
PMID: 32561400 [PubMed - as supplied by publisher]

Source: Experimental Gerontology - June 15, 2020 Category: Geriatrics Authors: Chiche A, Chen C, Li H Tags: Exp Gerontol Source Type: research