Sorbitol as a Polar Pharmacological Modifier to Enhance the Hydrophilicity of 99mTc-Tricarbonyl-Based Radiopharmaceuticals.
We report a novel glycated (sorbitol-containing) alkyne substrate for the "Click-to-Chelate" methodology, which is potentially of general applicability for the development of 99mTc-tricarbonyl based radiotracers displaying an enhanced hydrophilicity.
PMID: 32527027 [PubMed - in process]
Source: Nuklearmedizin - Category: Radiology Authors: Giammei C, Balber T, Benčurová K, Cardinale J, Berroterán-Infante N, Brandt M, Jouini N, Hacker M, Mitterhauser M, Mindt TL Tags: Molecules Source Type: research