RIPK1: a rising star in inflammatory and neoplastic skin diseases

Receptor-interacting serine threonine kinase 1 (RIPK1), a key driver of various pathways of inflammation downstream of tumor necrosis factor receptor 1 (TNFR1), Fas ligand (FasL), tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), Toll-like receptors (TLRs), as well as correlated with interferon and interleukin 1 α (IL-1α), is a multifunctional protein involved in regulating cell death and NF-κB signaling pathway [1–6]. RIPK1 contains N-terminal serine / threonine kinase domain, C-terminal death domain (DD) and intermediate domain (ID) which contains a RIP homotypic interaction motif (RHIM) domain.

Source: Journal of Dermatological Science - June 9, 2020 Category: Dermatology Authors: Jin Liping, Liu Panpan, Yin Mingzhu, Zhang Mi, Kuang Yehong, Zhu Wu Tags: Review article Source Type: research