Discovery of important molecular mechanism of Charcot-Marie-Tooth disease

(Forschungsverbund Berlin) Researchers from the Leibniz-Forschungsinstitut f ü r Molekulare Pharmakologie (FMP) in Berlin, in collaboration with colleagues from Milan, Paris and Mexico, have been able to highlight a new molecular mechanism of the Charcot-Marie-Tooth disease: According to their discovery, the protein Rab35 and the mTOR signaling pathway it regulates play a central role in the formation of myelin sheaths in the peripheral nervous system. First in-vivo experiments show that new therapies can be derived from the findings.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news