Corneal Cross-linking: Epi-On vs. Epi-Off Current Protocols, Pros, and Cons

AbstractPurpose of ReviewTo review the current protocols for corneal cross-linking for the treatment of keratoconus, including a comparison of epithelial off (Epi-off) and epithelial on (Epi-on) treatments.Recent FindingsAfter over 15  years of investigation, corneal cross-linking was approved in the USA in 2016. While Epi-off cross-linking is safe and effective, it is also associated with some drawbacks. Therefore, Epi-on is being investigated as a safer alternative. This paper reviews traditional Epi-off cross-linking and the latest Epi-on protocols.SummaryWhile Epi-on protocols are being evaluated and have shown potential for success, most studies have shown Epi-off to be more effective. However, the well-known risks associated with Epi-off treatment may be significantly mitigated with Epi-on treatment. Therefore, if Epi-on proves to be as effective as Epi-off, and gains approval, it may become the preferred procedure.
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research