Programmed genome rearrangements in ciliates.

Programmed genome rearrangements in ciliates.
Cell Mol Life Sci. 2020 May 27;:
Authors: Rzeszutek I, Maurer-Alcalá XX, Nowacki M
Abstract
Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as DNA amplification. In this review, we discuss the similarities and differences in the genome reorganization processes of the model ciliates Paramecium and Tetrahymena (class Oligohymenophorea), and the distantly related Euplotes, Stylonychia, and Oxytricha (class Spirotrichea).
PMID: 32462406 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - May 26, 2020 Category: Cytology Authors: Rzeszutek I, Maurer-Alcalá XX, Nowacki M Tags: Cell Mol Life Sci Source Type: research