Regulation of matrix metalloproteinase-1 by Filifactor alocis in human gingival and monocytic cells

ConclusionsOur results demonstrate thatF. alocis and MMP-1 are more prevalent at periodontitis sites. Additionally, our study provides original evidence thatF. alocis can stimulate MMP-1 production by fibroblastic and monocytic cells, suggesting thatF. alocis may contribute to periodontal breakdown through MMP-1.Clinical relevanceF. alocis and MMP-1 are linked to each other and key players in periodontitis, which may have significant implications for future diagnostic and treatment strategies.

Source: Clinical Oral Investigations - May 29, 2020 Category: Dentistry Source Type: research