Three-dimensional genome rewiring during the development of antibody-secreting cells.

Three-dimensional genome rewiring during the development of antibody-secreting cells.
Biochem Soc Trans. 2020 May 26;:
Authors: Chan WF, Johanson TM, Allan RS
Abstract
The development of B lymphocytes into antibody-secreting plasma cells is central to the adaptive immune system in that it confers protective and specific antibody response against invading pathogen. This developmental process involves extensive morphological and functional alterations that begin early after antigenic stimulation. These include chromatin restructuring that is critical in regulating gene expression, DNA rearrangement and other cellular processes. Here we outline the recent understanding of the three-dimensional architecture of the genome, specifically focused on its contribution to the process of B cell activation and terminal differentiation into antibody-secreting cells.
PMID: 32453419 [PubMed - as supplied by publisher]

Source: Biochemical Society Transactions - May 25, 2020 Category: Biochemistry Authors: Chan WF, Johanson TM, Allan RS Tags: Biochem Soc Trans Source Type: research