Tau Inhibitor Promising in Rapidly Progressing Dementia Type Tau Inhibitor Promising in Rapidly Progressing Dementia Type

An experimental tau inhibitor in development for Alzheimer's also has significant pharmacologic activity in bvFTD, a rare, rapidly progressive type of dementia that affects those younger than 65.Medscape Medical News
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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Authors: Brenowitz WD, Kaup AR, Yaffe K Abstract INTRODUCTION: We created a summary score for multiple sensory (multisensory) impairment and evaluated its association with dementia. METHODS: We studied 1794 adults aged 70 to 79 who were dementia-free at enrollment and followed for up to 10 years in the Health, Aging, and Body Composition Study. The multisensory function score (0 to 12 points) was based on sample quartiles of objectively measured vision, hearing, smell, and touch summed overall. Risk of incident dementia and cognitive decline (measured by two cognitive tests) associated with the score were asses...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, Gearhart D, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grossman M, Haley D, Heuer H, Hsiung GY, Huey E, Irwin D, Jones D, Jones L, Kantarci K, Karydas A, Knopman D, Kornak J, Kramer J, Kukull W, Lucente D, Lungu C, Mackenzie I, Manoochehri M, McGinnis S, Miller B, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin K, Rascovsky K, Sengdy P, Shaw L, Tatton N, Taylor J, Toga A, Trojano...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Obesity and its immediate consequences, such as non-alcoholic fatty liver disease and type 2 diabetes, are associated with greater neuroinflammation and risk of dementia. Excess visceral fat tissue does its part to produce chronic inflammation throughout the body, but here researchers focus on a specific metabolic dysregulation in the liver that produces inflammation in the brain. That inflammation in turn drives a faster progression towards neurodegenerative conditions. The lesson here, as in so much of this research: don't get fat, don't stay fat. You won't like the consequences. Researchers have revealed the ca...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.0c00391
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
ABSTRACT Objective Evaluate the accuracy of two semantic categories of the verbal fluency test (supermarket and animal categories) to separate healthy elderly individuals and lower educated Alzheimer ’ s disease patients. Methods We evaluated 69 older adults with less than 5 years of schooling, consisting of 31 healthy elderly, and 38 patients diagnosed with Alzheimer ’ s disease. Semantic verbal fluency was evaluated using the animal and supermarket categories. Mann-Whitney U and Independent t Tests were used to compare the two groups, and the diagnostic accuracy of the tests was analyzed by sensitivity, speci...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
AbstractPurpose of ReviewPrimary age-related tauopathy (PART) was recently proposed as a pathologic diagnosis for brains that harbor neurofibrillary tangles (Braak stage ≤ 4) with little, if any, amyloid burden. We sought to review the clinicopathologic findings related to PART.Recent FindingsMost adult human brains show at least focal tauopathic changes, and the majority of individuals with PART do not progress to dementia. Older age and cognitive impairment correlate with increased Braak stage, and multivariate analyses suggest that the rate of cognitive decline is less than matched patients with Alzheimer dise...
Source: Current Neurology and Neuroscience Reports - Category: Neuroscience Source Type: research
The relationship between depression and Alzheimer ’s disease (AD) is complex and still not well understood. We aimed to examine the roles of the AD core pathologies in modulating the associations of minimal depressive symptoms (MDS) with cognitive impairments.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research
Abstract To evaluate functional capacity, mobility and balance in elderly patients with Alzheimer's Disease (AD), in its mild, moderate and severe forms, verifying the existence of correlation among these parameters. Eighty-eight elderly patients (81.79 ± 6.54 years) diagnosed with AD treated at an elderly care reference center in Taguatinga-DF were selected, and information was collected between November 2018 and March 2019. Data collection was initially made by filling in the evaluation form. Subsequently, two questionnaires were administered to caregivers (Clinical Dementia Rating-CDR and Disability Assessment fo...
Source: Revista Brasileira de Cineantropometria e Desempenho Humano - Category: Sports Medicine Source Type: research
Conditions:   Alzheimer Disease;   Mild Cognitive Impairment Interventions:   Drug: Flortaucipir F18;   Procedure: Brain PET scan Sponsor:   Avid Radiopharmaceuticals Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those workin...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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