Implication of the zinc-epigenetic axis in epidermal homeostasis

Zinc deficiency (ZD) first manifests in the skin [1]. ZD leads to fragility and defects in the barrier function of the skin. A human skin equivalent model was generated, to investigate the association between ZD and regulation of acetylation, using 1 μM of TPEN (N,N,N,N-Tetrakis(2-pyridylmethyl)-ethylenediamine), a zinc specific chelator, to mimic ZD. This concentration did not show cytotoxicity (Fig. S1). We found that ZD induced improper stratification with an easily cracked stratum corneum (Fig.

Source: Journal of Dermatological Science - May 24, 2020 Category: Dermatology Authors: Mi-Gi Lee, Sehyun Chae, Kimiko Nakajima, Miho Ibi, Hozumi Sano, Takafumi Hara, Hantae Jo, Teruhisa Takagishi, Byungsun Cha, Jin-myoung Baek, Emi Yoshigai, Takuto Ohashi, Tarou Iri é, Shigetoshi Sano, Jong-Soo Lee, Toshiyuki Fukada, Bum-Ho Bin Tags: Letter to the Editor Source Type: research