Combined G-CSF and Plerixafor enhance hematopoietic recovery of CD34+ cells from poor mobilizer patients in NSG mice

Hematopoietic stem/progenitor cells (HSPC) contained in the CD34+ cell compartment give rise to all blood cell types and have been used for decades in transplantation [1, 2]. Nowadays, the main source of transplantable HSC comes from G-CSF-mobilized peripheral blood and the minimal number of mobilized CD34+ cells (mCD34+) for autologous transplantation is 2.106 CD34+ cells/kg body weight [3]. Moreover, up to 30% patients fail to mobilize enough CD34+ cells after G-CSF treatment [4-6]. The combination of G-CSF plus Plerixafor, a CXCR4 chemokine receptor inhibitor, was shown to improve and increase the number of mCD34+ [7], which represented an improved mobilization protocol to overcome the mCD34+ number limitation.

Source: Experimental Hematology - May 21, 2020 Category: Hematology Authors: M.L. Arcangeli, P. Brault, J.H. Bourhis, F. Kuhnowski, E. Henry, V. Barroca, S. Koscielny, F. Pflumio, S. Amsellem Source Type: research