Differential Requirement for CCR6 in IL-23 –Mediated Skin and Joint Inflammation

CCR6 is important for the trafficking of IL-17A –producing γδ T cells and required for the development of psoriasiform dermatitis in an IL-23 intradermal injection model. The role of CCR6, however, in IL-23–mediated joint inflammation is unclear. We herein hydrodynamically delivered IL-23 minicircle DNA into wild-type and CCR6-deficient (CC R6-knockout) mice to induce overexpression of IL-23 systemically. After IL-23 gene transfer, wild-type mice exhibited concurrent skin and joint changes that recapitulate some features found in human psoriatic skin and joints.

Source: Journal of Investigative Dermatology - April 23, 2020 Category: Dermatology Authors: Zhenrui Shi, Emma Garcia-Melchor, Xuesong Wu, Sebastian Yu, Mimi Nguyen, Douglas J. Rowland, Mindy Huynh, Timothy Law, Siba P. Raychaudhuri, Neal L. Millar, Samuel T. Hwang Tags: Original Article Source Type: research