Learning from the past: Mitomycin C use in trabeculectomy and its application to bleb-forming minimally invasive glaucoma surgery

Trabeculectomy has been performed since the mid-1960s and remains the gold standard for glaucoma surgery. Newer surgical options have evolved, collectively referred to as minimally invasive glaucoma surgeries (MIGS). Despite producing large intraocular pressure decreases, full-thickness procedures into the subconjunctival space may be limited by fibrosis. Application of 5-fluorouracil and mitomycin-C (MMC) have been in use with trabeculectomy with good evidence of significantly increased success, at the cost, however of an increased risk of complications.

Source: Survey of Ophthalmology - May 21, 2020 Category: Opthalmology Authors: Katharina Bell, Bernardo de Padua Soares Bezerra, Mathabo Mofokeng, Giovanni Montesano, Monisha Esther Nongpiur, Maria Vidal Marti, Mitchell Lawlor Tags: Major review Source Type: research