FMT Helps Without Clearing Multidrug-Resistant Organisms FMT Helps Without Clearing Multidrug-Resistant Organisms

For seriously ill patients with multidrug-resistant organisms in their gastrointestinal tract, fecal microbiota transplant (FMT) might result in fewer and less severe infections, investigators report.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news

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AbstractThe introduction of hepatobiliary contrast agents, most notably gadoxetic acid (GA), has expanded the role of MRI, allowing not only a morphologic but also a functional evaluation of the hepatobiliary system. The mechanism of uptake and excretion of gadoxetic acid via transporters, such as organic anion transporting polypeptides (OATP1,3), multidrug resistance-associated protein 2  (MRP2) and MRP3, has been elucidated in the literature. Furthermore, GA uptake can be estimated on either static images or on dynamic imaging, for example, the hepatic extraction fraction (HEF) and liver perfusion. GA-enhanced MRI h...
Source: Abdominal Imaging - Category: Radiology Source Type: research
Conclusion Infection (particularly HCAi) adds mortality risk to any level of liver dysfunction in decompensated liver cirrhosis patients. Mechanisms of long(er)-term effects (in acute episode survivors) seemingly include enhanced deterioration of liver function.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Conclusions: AT after KP confirmed conflicting results; therefore, multicentered, prospective, randomized control studies are needed to better understand its utility after KP, especially in the multidrug resistance spread era.
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
In conclusion, our results show that there is a great variety of adhesion phenotypes in multidrug-resistant strains that colonize transplanted patients.
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Over the past several decades, human gut microbes have been under constant antibiotic assault in the form of medical therapies, resulting in the deterioration of microbiomes. Alterations in gut microbiota are linked to irritable bowel syndrome, inflammatory bowel diseases, asthma, allergic diseases, cardiovascular diseases, metabolic syndrome, autoimmune diseases, and even neurological diseases.1,2
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Even if the incidence of tuberculosis (TB) has been decreasing over the last years, the number of patients with TB is increasing worldwide. The emergence of multidrug-resistant and extensively drug-resistant TB is making control of TB more difficult. Mycobacterium bovis bacillus Calmette–Guérin vaccine fails to prevent pulmonary TB in adults, and there is an urgent need for a vaccine that is also effective in patients with human immunodeficiency virus (HIV) coinfection. Therefore, TB control may benefit on novel therapeutic options beyond antimicrobial treatment. Host-directed immunotherapies could offer thera...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Effect of ABCB1 3435C>T Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult Renal Transplant Recipients: a Systematic Review and Meta-analysis. Clin Ther. 2020 Sep 01;: Authors: Peng W, Lin Y, Zhang H, Meng K Abstract PURPOSE: Tacrolimus is the substrate of multidrug-resistance 1 (ABCB1). However, the effect of ABCB1 C3435T polymorphism on pharmacokinetic variables of tacrolimus is controversial in different studies. This meta-analysis was conducted to explore the relationship between ABCB1 3435C>T genetic polymorphism and pharmacokinetic variables of tacrolimus. METHOD...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research
This article highlights the difficult balance between immunosuppression for graft-versus-host disease therapy and refractory CMV treatment, with a review of CMV antiviral therapy.
Source: Infectious Diseases in Clinical Practice - Category: Infectious Diseases Tags: Review Articles Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
Purpose of review The review of infections in lung transplantation is beyond the scope of this article as it is a comprehensive topic, however we aim to focus on infections with multidrug-resistant (MDR) microorganisms in this patient population. Recent findings New emerging clinical studies have provided data regarding outcomes in lung transplant recipients with MDR bacterial infections. Summary Isolation of MDR bacteria from lung donors preoperatively has not been associated with worse outcomes in recipients. Patients with cystic fibrosis colonized with MDR bacteria do not have increased 1 year mortality rates co...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: INFECTIOUS DISEASES: Edited by Emily Blodget Source Type: research
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