Can a Novel Scoring System Improve on the Mirels Score in Predicting the Fracture Risk in Patients with Multiple Myeloma?

CONCLUSION: The novel scoring system was found to be more sensitive than the Mirels system for predicting pathologic fracture in our retrospective cohort of patients with multiple myeloma-related bone disease. Specificity, PPV, NPV, and ROC AUC were not different with the numbers available. Thus, the novel scoring system may serve as a more effective screening tool to determine which patients with multiple myeloma would benefit from further radiologic or orthopaedic evaluation based on a skeletal survey. LEVEL OF EVIDENCE: Level III, diagnostic study. PMID: 32420721 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32420721?dopt=Abstract

Source: Clinical Orthopaedics and Related Research - May 10, 2020 Category: Orthopaedics Authors: Toci GR, Bressner JA, Morris CD, Fayad L, Levin AS Tags: Clin Orthop Relat Res Source Type: research