Frequentist Analysis of Death Associated With Intravitreal Anti –Vascular Endothelial Growth Factor Therapy

We present some complementary frequentist meta-analysis to an article published. The authors only used articles published in the English language. Although with the Peters and Egger test, they did not find a publication bias (P  = .44; P = .19), when analyzing the funnel plot graph, an asymmetry is evidenced. This may reflect a selection bias by language; there is a lack of small articles that should have a result in the direction of a higher risk of mortality, so the presence of this bias may favor statistical non significance and must be taken into account when interpreting the results.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research