Rationale and study design for lifestyle intervention in preparation for pregnancy (LIPP): A randomized controlled trial

Maternal obesity increases neonatal risk for obesity and metabolic syndrome later in life. Prior attempts to break this intergenerational obesity cycle by limiting excessive gestational weight gain have failed to reduce neonatal adiposity. Alternatively, pre-conception lifestyle interventions may improve the in utero metabolic milieu during early pregnancy leading to improved fetal outcomes. This randomized controlled trial (RCT) is evaluating whether a lifestyle intervention to reduce weight and improve maternal metabolism in preparation for pregnancy (LIPP) attenuates neonatal adiposity, compared to standard medical advice.

Source: Contemporary Clinical Trials - May 9, 2020 Category: Radiology Authors: M.L. Erickson, J.M. Mey, C.L. Axelrod, D. Paul, L. Gordesky, K. Russell, H. Barkoukis, P. O'Tierney-Ginn, R.A. Fielding, J.P. Kirwan, P.M. Catalano Source Type: research