Microbiome Metabolite Mimics Accelerate Drug Discovery.

Microbiome Metabolite Mimics Accelerate Drug Discovery. Trends Mol Med. 2020 May;26(5):435-437 Authors: Nuzzo A, Brown JR Abstract A recent study by Dvořák et al. supports metabolite mimicry as a drug development strategy. A potent agonist of the human pregnane X receptor (hPXR) was designed from two ligands that are products of the microbial catabolism of tryptophan. Its validity was demonstrated in cellular assays and a murine colitis model expressing hPXR by a significant reduction in inflammation biomarkers. PMID: 32359474 [PubMed - in process]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Tags: Trends Mol Med Source Type: research