Microbiome Metabolite Mimics Accelerate Drug Discovery.
Microbiome Metabolite Mimics Accelerate Drug Discovery.
Trends Mol Med. 2020 May;26(5):435-437
Authors: Nuzzo A, Brown JR
Abstract
A recent study by Dvořák et al. supports metabolite mimicry as a drug development strategy. A potent agonist of the human pregnane X receptor (hPXR) was designed from two ligands that are products of the microbial catabolism of tryptophan. Its validity was demonstrated in cellular assays and a murine colitis model expressing hPXR by a significant reduction in inflammation biomarkers.
PMID: 32359474 [PubMed - in process]
Source: Trends in Molecular Medicine - Category: Molecular Biology Authors: Nuzzo A, Brown JR Tags: Trends Mol Med Source Type: research
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