Lenticular fungal infection caused by Aspergillus in a patient with traumatic corneal laceration: a case report

To report a case of lenticular infection caused by Aspergillus, which was diagnosed 13  weeks after traumatic corneal laceration.
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Case report Source Type: research

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AbstractA primary immune deficiency disorder is often suspected in children with recurrent deep seated and fungal infections and those admitted to pediatric  intensive care units. Chronic granulomatous disease (CGD) is inherited disorder leading to infections caused due to defective superoxide production. Cases referred for testing for a primary immunodeficiency disorder were tested for Dihydrorhodamine 123 (DHR) assay by flow cytometry and nitroblue t etrazolium dye (NBT) slide test. The unstimulated and stimulated samples were tested for oxidative burst activity which gives bright fluorescence due to formation of Rh...
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
Pulmonary infections with Aspergillus fumigatus (Af) are a significant cause of invasive fungal disease and lead to high morbidity and mortality in diverse populations throughout the world. Currently available antifungal drugs are often ineffective, thus contributing to unacceptably high mortality rates in patients suffering from invasive fungal infections. The use of cytokines as adjunctive immune therapies holds the promise of significantly improving patient outcomes in the future. In recent studies, we identified an essential role for type I and III interferons as regulators of optimal antifungal responses by pulmonary ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
The role of antifungal prophylaxis in acute myeloid leukemia (AML) continues to be controversial, with national guidelines recommending prophylaxis based on incidence of invasive fungal infection (IFI) to each region. We performed a retrospective, interrupted time series study based on periods where fluconazole was used or not used as prophylaxis during induction for AML. There was a decrease in IFI with fluconazole; however, this was largely driven by probable Aspergillus infection seen in our non-prophylaxis cohort. Our results suggest further investigation of azoles is warranted with consideration of including risk adap...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
AbstractPurpose of ReviewThis review describes the clinical presentation, predisposing factors, pathophysiology, mycology, diagnosis, and therapy of sino-orbital invasive fungal infections in immunocompetent individuals. Recent advances published in the literature were reviewed with special consideration of current diagnostic methods and treatment regimens.Recent FindingsOwing to the rarity of this condition literature is scarce. Majority of the studies are from tropical countries such as India where the disease is relatively more common. Treatment strategies are variable and response to medical treatment is favorable in s...
Source: Current Fungal Infection Reports - Category: Infectious Diseases Source Type: research
ConclusionsBronchoscopy could be a reliable procedure for TBA diagnosis in critically ill non ‐neutropenic patients. Whitish plaques ± ulcers were the prominent bronchoscopic changes with reasonable diagnostic accuracy for prediction of TBA.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
(Canadian Glycomics Network) Aspergillus fumigatus is a fungal species that can cause serious illnesses in immunocompromised individuals. Infections caused by A. fumigatus are difficult to eliminate because the fungus often aggregates into small communities called " biofilms, " which protect the pathogens from antifungal agents and help the fungus evade the immune system. GlycoNet scientists Drs. Lynne Howell and Don Sheppard recently identified a key enzyme in A. fumigatus that could lead to therapeutics to treat these fungal infections.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
up MC Abstract Manogepix (APX001A) is the active moiety of the drug candidate fosmanogepix (APX001), currently in clinical development for the treatment of invasive fungal infections. We compared manogepix EUCAST MECs to MICs of five comparators, to CLSI MECs and to MICs by a colorimetric method against contemporary moulds.EUCAST susceptibility testing was performed for 161 isolates. Inter-laboratory and inter-method reproducibility were determined by comparison with published manogepix MECs. Colorimetric MICs (measuring metabolic activity) were evaluated using three A. fumigatus and one A. flavus isolates with fo...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Abstract Many fungal diseases remain poorly addressed by public health authorities, despite posing a substantial threat to humans, animals, and plants. More worryingly, few classes of anti-fungals have been developed to combat fungal infections thus far. These medications also have certain drawbacks in terms of toxicity, spectrum of activity, and pharmacokinetic properties. Hence, there is a dire need for discovery of novel anti-fungal agents. Melittin, the main constituent in the venom of European honeybee Apis mellifera, has attracted considerable attention among researchers owing to its potential therapeutic ap...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
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