Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.

CONCLUSIONS: Treatment of skin with organic osmolytes modulates TJ structure and function, which could contribute to the epidermal barrier. This emphasises a role for organic osmolytes beyond the maintenance of intracellular osmolarity. This could be harnessed to enhance topical therapies for diseases characterised by skin barrier dysfunction.
PMID: 32348549 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - April 28, 2020 Category: Dermatology Authors: El-Chami C, Foster AR, Johnson C, Clausen RP, Cornwell P, Haslam IS, Steward MC, Watson REB, Young HS, O'Neill CA Tags: Br J Dermatol Source Type: research