Three new quassinoids isolated from the wood of Picrasma javanica and their anti-Vpr activities

AbstractThree new quassinoids, javanicinols A and B (1 and2) and 4-keto-(16S)-methoxyjavanicin B (3), together with three known quassinoids (4 –6) were isolated from the chloroform-soluble fraction of the methanol extract of thePicrasma javanica wood. The structures of1 –3 were determined by spectroscopic analyses, including 1D and 2D NMR, HRESIMS, and CD. The anti-HIV-1 viral protein R (Vpr) assay revealed that1 and2 exhibited potent anti-Vpr activities at 1.25  μM. Furthermore, the assay also revealed the potent anti-Vpr activities of (16R)-methoxyjavanicin B (7) and (16S)-methoxyjavanicin B (8), which were previously isolated from thePicrasma javanica wood.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research