Depth of injury of Hetter's phenol-croton oil chemical peel formula using 2 different emulsifying agents

To the Editor: Deep  chemical peels consist of the application of a mixture of phenol, croton oil, water, and, historically, a handwash soap containing triclosan and sodium C14-16 olefin sulfonate as the emulsifying agent (Septisol [SEP], Steris Corp, Mentor, OH).1 Because of the US Food and Drug Administration's fina l rule on hand sanitizers,2 which prohibits the use of triclosan, SEP was discontinued. The classic Baker-Gordon's formula3 (2.1% croton oil/49.3% phenol) and Hetter's standardized formulas (0.1%-1.6% croton oil/35% phenol) contained 5% SEP, which generated a very unstable emulsion1 that spontaneou sly separated into 2 distinct layers (an upper and a lower layer) within minutes (Fig 1, A-D, right).

Source: Journal of the American Academy of Dermatology - March 1, 2020 Category: Dermatology Authors: Aline da Silva Justo, Bruna Mikulis Lemes, Bruna Nunes, Kevin Alves Antunes, Bruna Carletto, Adriana Yuriko Koga, Leandro Cavalcante Lipinski, Mario Rodrigues Montemor Netto, Eduardo Bauml Campagnoli, Fl ávio Luís Beltrame, Carlos Gustavo Wambier Tags: Letter Source Type: research