Multilevel characterization of antibody-ligand conjugates by CESI-MS.

CONCLUSION: The developed multilevel analytical method offers a comprehensive way to determine the localization and stoichiometry of antibody-drug conjugates for molecular medicinal applications. In addition, a significant advantage of the reported approach is that small, hydrophilic, unmodified peptides well separated from the neutrals, which is not common with other liquid phase separation methods such as LC.
PMID: 32294034 [PubMed - as supplied by publisher]

Source: Current Molecular Medicine - April 13, 2020 Category: Molecular Biology Authors: Fonslow B, Jarvas G, Szigeti M, Guttman A Tags: Curr Mol Med Source Type: research