Sigma ‐1 Receptor Activation‐Induced Glycolytic ATP Production and Endothelial Barrier Enhancement

ConclusionActivation of σ1 enhances endothelial barrier function and modulates the ratio of glycolytic versus mitochondrial ATP production. These novel findings suggest that endothelial σ1 may prove beneficial as a novel therapeutic target for reducing microvascular hyperpermeability and counteracting mitochondrial dysfu nction.

Source: Microcirculation - April 11, 2020 Category: Research Authors: Zeinab Y. Motawe, Forouzandeh Farsaei, Salma S. Abdelmaboud, Javier Cuevas, Jerome W. Breslin Tags: ORIGINAL RESEARCH Source Type: research