Emerging roles for non-coding RNAs in Autoimmune thyroid disease.

Emerging roles for non-coding RNAs in Autoimmune thyroid disease. Endocrinology. 2020 Apr 09;: Authors: Liang Y, Zeng C, Yao J, Shen J Abstract Autoimmune thyroid disease (AITD) is one of the most frequent autoimmune disorders. However, the pathogenesis of AITD has not been fully elucidated. Recently, accumulating evidences have demonstrated that abnormal expression of non-coding RNAs (ncRNAs) is closely related to the etiopathogenesis of AITD. microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are three major groups of ncRNAs, which attract increasing attention. Herein，we summarized our present knowledge on the role of microRNA, lncRNAs and circRNAs in AITD. This review focused on the importance of ncRNAs in development of the most prevalent AITD, such as Hashimoto's disease (HT) and Graves' diseases (GD). Altogether, the main purpose of this review is to provide new insights in the pathogenesis of AITD and the possibility to develop novel potential therapeutic targets. PMID: 32270194 [PubMed - as supplied by publisher]
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research