Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines

Synthesis DOI: 10.1055/s-0040-1707472 A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio­- and diastereoselectivities. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synthesis - April 6, 2020 Category: Chemistry Authors: Vetica, Fabrizio Bailey, Stephen J. Kumar, Mukesh Mahajan, Suruchi von Essen, Carolina Rissanen, Kari Enders, Dieter Tags: paper Source Type: research