Lack of Data-driven Treatment Guidelines and Wide Variation in Management of Chronic Pelvic Pain in Adolescents and Young Adults

Current literature lacks data-driven guidelines for surgical treatments of adolescents and young adults (AYAs) with chronic pelvic pain. We hypothesized that there is a significant variation in treatment of these patients, which may be an indicator of over or under treatment by some providers.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research

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a Patrizia Romualdi Sándor Benyhe Júlia Timár Helmut Schmidhammer Mariana Spetea Mahmoud Al-Khrasani There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, chronic treatment with opioid analgesics induces central analgesic tolerance, thus limiting their clinical usefulness. Numerous molecular mechanisms, including receptor desensitization, G-protein decoupli...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Condition:   Chronic Low-back Pain Interventions:   Behavioral: Cognitive Functional Therapy+;   Behavioral: Interdisciplinary pain management Sponsors:   Odense University Hospital;   University of Southern Denmark;   Curtin University;   Manchester Metropolitan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionDuloxetine treatment in patients with RA in clinical remission appears to have comparable effectiveness on relieving remnant pain, improving activities of daily living and maintaining QOL. Duloxetine is not expected to have any effects on disease activity control.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
AbstractChronic constipation is one of the five most common symptoms seen by gastroenterologist. In the absence of alarm symptoms, a confident symptom-based diagnosis can often be made using the Rome criteria. Three different subtypes have been identified to date: normal transit constipation, defaecatory disorders and slow transit constipation. Differentiation between these subtypes can be made through functional testing using tests such as anorectal manometry with balloon expulsion and a radio-opaque marker test. In general, patients are initially advised to increase their fluid and fibre intake. When these general lifest...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Condition:   Chronic Low-back Pain Interventions:   Behavioral: Cognitive Functional Therapy+;   Behavioral: Interdisciplinary pain management Sponsors:   Odense University Hospital;   University of Southern Denmark;   Curtin University;   Manchester Metropolitan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Chronic pain is highly prevalent in the working population. People tend to attempt self-initiated treatments to manage their pain. The self-efficacy of behavioural change is a suitable model for guiding the de...
Source: Trials - Category: General Medicine Authors: Tags: Study protocol Source Type: research
Condition:   Chronic Low-back Pain Interventions:   Behavioral: Cognitive Functional Therapy+;   Behavioral: Interdisciplinary pain management Sponsors:   Odense University Hospital;   University of Southern Denmark;   Curtin University;   Manchester Metropolitan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeThis is a retrospective cohort study that evaluates the postoperative pain findings of a consecutive series of laparoscopic surgeries for deep endometriosis (DE).MethodsThis multi-center retrospective cohort study was carried out in university hospitals (Istanbul, Turkey). Sixty-five patients diagnosed through bimanual gynecologic examination, gynecologic ultrasound or magnetic resonance imaging-confirmed endometrioma and DE together; who underwent a laparoscopic surgery between 2013 and 2019 by a team of gynecologists, colorectal surgeons, and a urologist were retrospectively evaluated. The data were collec...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionsClinicians should look for any evidence of central neuropathic pain for at least 12  months after stroke. Both pharmacological and non-pharmacological interventions can be used for the management of CPSP. Lamotrigine has the strongest evidence (Level II of evidence, derived from small randomized controlled trials) for being effective in the management of CPSP. Future research sho uld focus on well-designed trials of pharmacological and non-pharmacological interventions aiming to relief CPSP, which is a very common but often neglected pain syndrome.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Cognition is an important function of the brain that enables us to acquire and process information, to enhance our understanding of thoughts, experiences, and our senses. Any condition that affects our ability to think, reason, memorize, or be attentive affects our cognitive ability. Some cognitive decline is a normal part of aging, but there are many things you can do to prevent or forestall cognitive changes as you age, including when planning for surgery. Older adults are having more surgical procedures As our population ages and medicine and healthcare advances, more older adults are likely to develop serious condition...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Healthy Aging Managing your health care Memory Neurological conditions Prevention Surgery Source Type: blogs
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