Successive xanthogranulomatous prostatitis after complete remission of metastatic prostate adenocarcinoma: An extremely rare case report with review of literatures
Publication date: Available online 3 April 2020Source: Urology Case ReportsAuthor(s): Che-Hsueh Yang, Chin-Heng Lu, Li-Hua Huang, Yen-Chuan Ou, Chao-Yu Hsu, Min-Che Tung
This study is aimed to screen potential DNA methylation signatures to facilitate the diagnosis and prognosis of LUAD and integrate gene expression and DNA methylation data of LUAD to identify functional epigenetic modules. We systematically integrated gene expression and DNA methylation data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO), bioinformatic models and algorithms were implemented to identify signatures and functional modules for LUAD. Three promising diagnostic and five potential prognostic signatures for LUAD were screened by rigorous filtration, and our tumor-normal classifier and progno...
Conditions: Breast Cancer; Breast Neoplasms; Breast Adenocarcinoma; Breast Cancer Recurrent; Breast Cancer Metastatic; Breast Cancer Invasive; Non-small Cell Lung Cancer; Non-small Cell Carcinoma; Non-small Cell Lung Cancer Recurrent; Non-Small Cell Squamous L ung Carcinoma; Non-Small Cell Adenocarcinoma; Non-small Cell Lung Cancer Metastatic; Colorectal Cancer; Colorectal Neopla...
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Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
In this study, we applied Drop-seq, a high throughput single cell RNA-seq platform, to characterize the different cell types present in pancreatic cancer organoids. We sequenced the transcriptomes of 7675 single cells from organoids derived from a patient undergoing a Whipple procedure for pancreatic ductal adenocarcinoma (PDAC). We then developed a novel clustering approach based on a class of probabilistic generative models called topic models, leading to the identification of subpopulations of cells.
Contributors : Isabel R Calvo ; Miguel Brown ; Kori Kirby ; Samantha SparrowSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensRNA sequencing demonstrates molecular profiles common to primary tumor, PDX and organoid models
Cell Death &Disease, Published online: 01 June 2020; doi:10.1038/s41419-020-2553-6CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation
Conclusions: We identified a robust set of new potential key genes in PCa, which would provide reliable biomarkers for early diagnosis and prognosis and would promote molecular targeting therapy for PCa.
This study sought to develop diagnostic algorithms using multiple biomarker panels and to validate their performance in the diagnosis of pancreatic ductal adenocarcinoma (PDAC). We used blood samples from 180 PDAC patients and 573 healthy controls. Candidate markers consisted of 11 markers that are commonly expressed in various cancers and which have previously demonstrated increased expression in pancreatic cancer. Samples were divided into training and validation sets. Five linear or non-linear classification methods were used to determine the optimal model. Differences were identified in 10 out of the 11 markers tested....