Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6 (-Iodomethyl-norcholesterol Scintigraphy.

Ectopic Cortisol-producing Adrenocortical Adenoma Detected by 131I-6 (-Iodomethyl-norcholesterol Scintigraphy. Intern Med. 2020 Apr 02;: Authors: Sato S, Imachi H, Kobayashi T, Fukunaga K, Lyu J, Dong T, Yoshioka Y, Saheki T, Fukata Y, Natsuki B, Kurumi U, Kadota K, Murao K Abstract A 50-year-old man was referred to our department for overt Cushing's syndrome (CS). His plasma cortisol concentrations were 314 μg/L, and his urinary cortisol concentrations were 431 μg/day. The plasma ACTH concentration was below the detectable limit. Computed tomography revealed atrophy of both adrenal glands and the presence of a left pararenal tumor. 131I-6β-iodomethyl-norcholesterol scintigraphy showed an intense uptake by the left pararenal tumor. These findings suggested that the left pararenal tumor was ectopic cortisol-producing adrenocortical adenoma. This case serves as a reminder that 131I-6β-iodomethyl-norcholesterol scintigraphy is an effective method for diagnosing ACTH-independent CS in which no adrenal tumor has been found. PMID: 32238722 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research