GSE140013 Next Generation Sequencing Transcriptome Quantitative Analysis of Placenta of at embryonic day 19

Contributors : Lucas C Pantaleao ; Susan E Ozanne ; Ania WilczynskaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusObesity during pregnancy is associated with fetal growth restriction in the offspring. We used RNA next generation sequencing analysis (HiSeq2000) to have a snapshot of the placenta transcriptome at embryonic day 19 to examine whether mice exposed to maternal obesity had significant changes in their transcriptome which may lead to growth restriction in the fetus.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

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CONCLUSION: We identified modifiable maternal risk factors associated with neonatal seizures among low-risk pregnancies at term. Though infrequent, neonatal seizures are associated with higher risk of adverse outcomes in neonatal-maternal dyads. PMID: 32459434 [PubMed - in process]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Conditions:   Gestational Diabetes;   Pre-Eclampsia;   Type2 Diabetes;   Chronic Hypertension Complicating Pregnancy;   Primary Hypertension After Pregnancy;   Obesity Interventions:   Behavioral: Alternative Lifestyle Interventions in Vulnerable Ethnic groups;   Behavioral: Diabetes Prevention Program (DPP) online;   Behavioral: Standard of Care Sponsors:   Vanderbilt University Medical Center;   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
[The Conversation Africa] Pregnancy has been described as a "teachable moment" for promoting healthy lifestyle choices. This is because pregnant women are highly motivated to make behavioural changes. Whether the change involves taking a prescribed medication or supplement, or giving up a risky behaviour such as smoking, pregnant women are more committed because they feel a responsibility towards the health and well-being of their unborn child.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
Conclusions: Maternal health risks were associated with increased adult preventive visits, but 38% of dyads had no adult preventive visits in the year following birth. Most dyads had more opportunities for preventive care in pediatric settings than adult settings.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
Abstract Intestinal alkaline phosphatase (IAP) is an endogenous enzyme that promotes gastrointestinal homeostasis by detoxifying inflammatory mediators, tightening the gut barrier and promoting a healthy microbiome. Oral IAP administration was efficacious in ameliorating diabetes in a high fat diet (HFD) induced murine model. In humans, maternal obesity and diabetes during pregnancy has been associated with an increased risk of autism spectrum disorders (ASD). In mice, HFD-induced maternal obesity lead to offspring with cognitive deficiency. Here we investigated whether IAP administration to obese dams could ameli...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
inson Preconception care (PCC) is acknowledged as a vital preventive health measure aiming to promote health today and for subsequent generations. We aimed to describe the content and context of PCC delivery in a very remote Australian Aboriginal Community Controlled Health Service setting. A retrospective audit was undertaken to identify what PCC was delivered between 2011 and 2018 to 127 Aboriginal women who had at least one pregnancy during this period. Of 177 confirmed pregnancies, 121 had received PCC prior to the pregnancy. Sexually transmissible infection screening (71%) was the most common care delivered, follo...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Authors: Noever K, Schubert J, Reuschel E, Timmesfeld N, Arabin B Abstract Introduction Maternal obesity and excessive gestational weight gain (GWG) affect the outcomes of women and their offspring. Our aim was to evaluate population-based data from Germany. Material and Methods Data from 583 633/791 514 mother-child pairs obtained from the perinatal database in Hesse for the period from 2000 to 2015 were used after excluding incomplete or non-plausible datasets. Early-stage pregnancy maternal body mass index (BMI) and GWG were evaluated. Significant outcome changes were calculated using linear or logistic regr...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Some pregnant women with COVID-19 do become severely ill, and the risk may be elevated for those who were obese or had conditions like asthma before pregnancy, a new study suggests.
Source: WebMD Health - Category: Consumer Health News Source Type: news
THURSDAY, May 21, 2020 -- Some pregnant women with COVID-19 do become severely ill, and the risk may be elevated for those who were obese or had conditions like asthma before pregnancy, a new study suggests. As with all things COVID-19, researchers...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Publication date: June 2020Source: The Lancet Diabetes &Endocrinology, Volume 8, Issue 6Author(s): Assiamira Ferrara, Monique M Hedderson, Susan D Brown, Samantha F Ehrlich, Ai-Lin Tsai, Juanran Feng, Maren Galarce, Santica Marcovina, Patrick Catalano, Charles P Quesenberry
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
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