Lower-Grade Gliomas: Predicting DNA Methylation Subtyping and its Consequences on Survival with MR Features

Publication date: Available online 30 March 2020Source: Academic RadiologyAuthor(s): Hongdan Zhang, Li Xu, Zhiping Zhong, Yupin Liu, Yu Long, Shuqin Zhou
Source: Academic Radiology - Category: Radiology Source Type: research

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This study is assessed an optimized ferroptosis gene panel for glioma treatment. MATERIAL AND METHODS We obtained 45 reports on ferroptosis-related proteins in PubMed and conducted a statistical test of the patients' overall survival (OS) in the TCGA GBMLGG and CGGA databases. The statistically significant genes were screened for an optimal panel, followed by GO and KEGG analysis and evaluated its correlation with known prognostic factors of glioma, including IDH1 mutation, methylated MGMT, tumor purity, 1p/19q LOH, and methionine cycle. RESULTS Eight genes panel (ALOX5, CISD1, FTL, CD44, FANCD2, NFE2L2, SLC1A5, and GOT1) ...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusions: Cerebral HGGs arising in midline structures rarely occur in pediatric patients with NF1 and present with extremely poor prognosis, worse than HGGs developing in non-NF1 patients, independent of the presence or absence of H3 K27M mutation. Imaging features of aggressive biological activity on advanced MRI or amino-acid PET imaging suggest prompt neuropathological and molecular investigations.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Pediatric diffuse intrinsic pontine glioma (DIPG) represents one of the most devastating and lethal brain tumors in children with a median survival of 12 months. The high mortality rate can be explained by the...
Source: Cerebrospinal Fluid Research - Category: Neurology Authors: Tags: Research Source Type: research
Conclusions: Our results suggest IDH1 mutant in gliomas is more likely to exhibit homogeneous signal intensity, less contrast enhancement and more inclined to cross the midline. Patients with IDH1 mutated, age ≤ 40, KPS scores> 80 before operation and low-grade glioma may have a longer life and better prognosis.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThis original human BBTB model allows a better understanding of the influence of DIPG on the BBTB ECs phenotype. Our data reveal that the chemoresistance described for DIPG does not come from the development of a “super BBB”. These results, validated by the absence of modification of drug transport through the BBTB ECs, point out the importance of understanding the implication of the different protagonists in the pathology to have a chance to significantly improve treatment efficiency.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research
Publication date: Available online 26 May 2020Source: NeuroImage: ClinicalAuthor(s): Martin Kocher, Christiane Jockwitz, Svenja Caspers, Jan Schreiber, Ezequiel Farrher, Gabriele Stoffels, Christian Filss, Philipp Lohmann, Caroline Tscherpel, Maximilian I. Ruge, Gereon R. Fink, Nadim J. Shah, Norbert Galldiks, Karl-Josef Langen
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study was to explore the roles of miR-424-5p/Bifunctional apoptosis regulator (BFAR) axis in glioma. Ninety-six pairs of human glioma tissues and their adjacent non-cancer tissues were collected. The levels of BFAR and miR-424-5p were detected by quantitative polymerase chain reaction (qPCR) in glioma tissues and cell lines. Moreover, the biological roles of miR-424-5p and BFAR in glioma cells were assessed. We found a miR-424-5p binding site in the 3'UTR of BFAR by using TargetScan 7.2 online database. The miR-424-5p level was dramatically decreased in glioma tissues and cell lines, and the BFAR expression was signif...
Source: Pathology Oncology Research - Category: Pathology Authors: Tags: Pathol Oncol Res Source Type: research
PER2 inhibits proliferation and stemness of glioma stem cells via the Wnt/β‑catenin signaling pathway. Oncol Rep. 2020 May 27;: Authors: Ma D, Hou L, Xia H, Li H, Fan H, Jia X, Niu Z Abstract Glioblastoma is a highly malignant tumor that contains stem‑like cells known as glioma stem cells (GSCs), which lare associated with an increased risk of glioma occurrence, recurrence and poor prognosis. Circadian clock gene, period circadian clock 2 (PER2) expression has been revealed to be inhibited in various types of cancer. However, the precise role and potential mechanisms of PER2 in GSCs remai...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
onstantini Perrotta Cinalli s: The natural history of non-optic central nervous system (CNS) tumors in neurofibromatosis type 1 (NF1) is largely unknown. Here, we describe prevalence, clinical presentation, treatment, and outcome of 49 non-optic CNS tumors observed in 35 pediatric patients (0–18 years). Patient- and tumor-related data were recorded. Overall survival (OS) and progression-free survival (PFS) were evaluated. Eighteen patients (51%) harbored an optic pathway glioma (OPG) and eight (23%) had multiple non-optic CNS lesions. The majority of lesions (37/49) were managed with a wait-and-see stra...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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